Title: Wired to be human: Insights from transcriptome analysis
Speaker: Prof. Ying ZHU 诸颖
Institutes of Brain Science, Fudan University
Time: 14:00-17:00 PM, April 8(Monday)
Venue: Room 300, 320 Yueyang Road
Host: Prof. Guang-Zhong Wang
CAS-MPG Partner Institute for Computational Biology
Abstract: Although the human brain is about three times as large as those of our closest living relatives, the nonhuman African great apes, increased size and neural cell counts alone fail to explain its characteristic functionalities. The brain has also undergone microstructural, connectional, and molecular changes in the human lineage, changes likely me-diated by divergent spatiotemporal gene expression. Our integrative analysis of tissue and single-cell transcriptomic data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.