中科院计算生物学重点实验室学术报告：The Impact of Demographic History on Human Complex Traits
Speaker：Charleston Chiang, Ph.D. Center for Genetic Epidemiology, Department of Preventive
Medicine, Keck School of Medicine, University of Southern California. Los Angeles, CA 90033,
Time : 10:00-11:30 am , Apr. 27（Friday）
Venue: Room 258, SIBS Main Building, Yueyang Road 320
Host：Prof. Shuhua Xu
CAS-MPG Partner Institute for Computational Biology
Title: The Impact of Demographic History on Human Complex Traits
How complex traits change through time is a central question in evolutionary biology and genetics. One of the major evolutionary forces that shaped the distribution of human complex traits is the demographic history of a population. Therefore, in order for human genetics to provide a compelling context for studying complex trait evolution, it is necessary to integrate trait mapping with a detailed knowledge of population history. A well-known example of demographic impact on complex traits is found in present-day Finland, where a population bottleneck in its founding has been suggested to be the reason a number of rare Mendelian disorders are disproportionately more prevalent in Finland. I will illustrate the impact of demographic history of a population on human complex traits by first drawing examples from European populations of Sardinia and Finland. By utilizing large-scale whole-genome or whole-exome sequencing datasets, I will describe our findings in delineating the population structure and history of these populations, and how the special population history empowered association studies. Finally, I will end by describing our ongoing investigation of the population structure, genetic ancestry, and local adaptation in Han Chinese using ultra-low coverage whole-genome sequencing data from > 10,000 individuals across China.
All are Welcome!