edf壹定发

全体研究组长

陈 雁
博士 研究员 博士生导师

中科院营养代谢和食品安全重点实验室

信号转导与营养相关疾病课题组组长

研究方向:以细胞信号通路研究入手,以动物模型为手段,试图揭示多种重大疾病的发病机制。

电子邮件(E-mail ) :ychen3@sibs.ac.cn

电话(Tel):021-54920916

传真(Fax):021-54920291

邮政编码 :200030

简历 & 研究方向

2017 – 至   今        edf壹定发上海营养与健康研究院 研究员,副院长

2004 – 2016年     edf壹定发上海生命科学研究院 研究员

   2008 – 2016年    edf壹定发上海生命科学研究院营养科学研究所 所长

   2006 – 2008年    edf壹定发上海生命科学研究院营养科学研究所 副所长

1998 – 2005年     美国Indiana大学医学和分子遗传系助理教授、副教授(已获终身教授)

1994 – 1998年     美国加利福尼亚大学圣地亚哥分校(UCSD)/Salk研究所博士后

1989 – 1994年     美国Indiana大学医学和分子遗传系博士

1983 – 1986年     华西医科大学儿科系硕士

1978 – 1983年     华西医科大学医学系医学学士

研究方向(1000字以内)

运用分子生物学、细胞生物学和模式动物探讨代谢性疾病和肿瘤发生的分子机制、信号转导以及与人类疾病的关系等方面的研究。研究主要集中在细胞内信号通路的空间调控对细胞功能和机体生理机能的影响,尤其是在肿瘤发生和糖脂代谢紊乱的生物学功能。

代表性论文(*通讯编辑

1. Zhao Z, Xu D, Wang Z, Wang L, Han R, Wang Z, Liao L, Chen Y*. Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation via the coordinated actions of PAQR3 and HUWE1. Hepatology. 2018 Jan 13. doi: 10.1002/hep.29786. [Epub ahead of print]

2. Guo W, You X, Wang X, Wang L, Chen Y*. A synthetic peptide hijacks the catalytic subunit of class I PI3K to suppress the growth of cancer cells. Cancer Lett. 2017 Oct 1;405:1-9.

3. Wang L, Zhang R, You X, Zhang H, Wei S, Cheng T, Cao Q, Wang Z, Chen Y*. The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis. J Mol Cell Biol. 2017 Sep 12:1-13.

4. You X, Guo W, Wang L, Hou Y, Zhang H, Pan Y, Han R, Huang M, Liao L, Chen Y*. Subcellular distribution of RAD23B controls XPC degradation and DNA damage repair in response to chemotherapy drugs. Cell Signal. 2017 Aug;36:108-116.

5. Wang L, Pan Y, Huang M, You X, Guo F, Chen Y*. PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling. Cell Signal. 2017 May;33:98-106.

6. Zhang Y, Hou Y, Liu C, Li Y, Guo W, Wu JL, Xu D, You X, Pan Y, Chen Y*. Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response. Free Radic Biol Med. 2016 Aug;97:38-49.

7. Xu D, Wang Z, Chen Y*. Two-layer regulation of PAQR3 on ATG14-linked class III PtdIns3K activation upon glucose starvation. Autophagy. 2016 Jun 2;12(6):1047-8.

8. Xu DQ, Wang Z, Wang CY, Zhang DY, Wan HD, Zhao ZL, Gu J, Zhang YX, Li ZG, Man KY, Pan Y, Wang ZF, Ke ZJ, Liu ZX, Liao LJ, Chen Y*. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J. 2016 Mar 1;35(5):496-514.

9. Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y*. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nat Commun. 2015 Aug 27;6:8100.

10. Gu J, Zhang Y, Xu D, Zhao Z, Zhang Y, Pan Y, Cao P, Wang Z, Chen Y*. Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver. J Lipid Res. 2015 Jul;56(7):1329-39.

11. Liu G, Sun L, Pan A, Zhu M, Li Z, ZhenzhenWang Z, Liu X, Ye X, Li H, Zheng H, Ong CN, Yin H, Lin X, Chen Y*. Nickel exposure is associated with the prevalence of type 2 diabetes in Chinese adults. Int J Epidemiol. 2015 Feb;44(1):240-8.

12. Liu G, Zhang Y, Liu C, Xu D, Zhang R, Cheng Y, Pan Y, Huang C, Chen Y*. Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. J Nutr. 2014 Jul;144(7):1009-15.

13. Ling ZQ, Guo W, Lu XX, Zhu X, Hong LL, Wang Z, Wang Z, Chen Y*. A Golgi-specific protein PAQR3 is closely associated with the progression, metastasis and prognosis of human gastric cancers. Ann Oncol. 2014 Jul;25(7):1363-72.

14. Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell. 2014 Jan 9;53(1):75-87.

15. Zhang Y, Xu D, Huang H, Chen S, Wang L, Zhu L, Jiang X, Ruan X, Luo X, Cao P, Liu W, Pan Y, Wang Z, Chen Y*. Regulation of glucose homeostasis and lipid metabolism by PPP1R3G-mediated hepatic glycogenesis. Mol Endocrinol. 2014 Jan;28(1):116-26.

16. Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, Zhang Y, Xiao F, Pan Y, Liu Y, Guo F, Chen Y*. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Endocrinology. 2013 Dec;154(12):4525-35.

17. Zhang R, Huang H, Cao P, Wang Z, Chen Y*, Pan Y. Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem. 2013 Apr 12;288(15):10275-85.

18. Wang X, Wang L, Zhu L, Pan Y, Xiao F, Liu W, Wang Z, Guo F, Liu Y, Thomas WG, Chen Y*. PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Diabetes. 2013 Feb;62(2):444-56.

19. Huang H, Jin T, Wang L, Wang F, Zhang R, Pan Y, Wang Z, Chen Y*. The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafish. J Biol Chem. 2013 Jan 25;288(4):2355-64.

20. Zhu L, Wang L, Luo X, Zhang Y, Ding Q, Jiang X, Wang X, Pan Y, Chen Y*. Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-β signaling pathway. J Biol Chem. 2012 Nov 16;287(47):39653-63.

21. Huang H, Jin T, He J, Ding Q, Xu D, Wang L, Zhang Y, Pan Y, Wang Z, Chen Y*. Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2158-70.

22. Luo X, Zhang Y, Ruan X, Jiang X, Zhu L, Wang X, Ding Q, Liu W, Pan Y, Wang Z, Chen Y*. Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes. 2011 May;60(5):1435-45.

23. Jiang Y, Xie X, Li Z, Wang Z, Zhang Y, Ling ZQ, Pan Y, Wang Z, Chen Y*. Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition. Cancer Res. 2011 Apr 15;71(8):2959-68.

24. Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, Bai O, Liu W, Xie X, Wang Z, Fang J, Chen Y*. RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene. 2010 Sep 30;29(39):5404-15.

25. Yang L, Zhang Y, Wang L, Fan F, Zhu L, Li Z, Ruan X, Huang H, Wang Z, Huang Z, Huang Y, Yan X, Chen Y*. Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22. J Hepatol. 2010 Aug;53(2):339-47.

26. Zhang C, Zhang M, Wang S, Han R, Cao Y, Hua W, Mao Y, Zhang X, Pang X, Wei C, Zhao G, Chen Y*, Zhao L*. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J. 2010 Feb;4(2):232-41.

27. Jiang Y, Xie X, Zhang Y, Luo X, Wang X, Fan F, Zheng D, Wang Z, Chen Y*. Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus. Mol Cell Biol. 2010 Jan;30(1):78-90.

28. Ding Q, Wang Z, Chen Y*. Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway. Cell Res. 2009 Mar;19(3):317-27.

29. Chen Q, Chen H, Zheng D, Kuang C, Fang H, Zou B, Zhu W, Bu G, Jin T, Wang Z, Zhang X, Chen J, Field LJ, Rubart M, Shou W, Chen Y*. Smad7 is required for the development and function of the heart. J Biol Chem. 2009 Jan 2;284(1):292-300.

30. Feng L, Xie X, Ding Q, Luo X, He J, Fan F, Liu W, Wang Z, Chen Y*. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14348-53.

31. Han R, Lai R, Ding Q, Wang Z, Luo X, Zhang Y, Cui G, He J, Liu W, Chen Y*. Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism. Diabetologia. 2007 Sep;50(9):1960-8.

32. Kuang C, Xiao Y, Yang L, Chen Q, Wang Z, Conway SJ, Chen Y*. Intragenic deletion of Tgif causes defectsin brain development. Hum Mol Genet. 2006 Dec 15;15(24):3508-19.

33. Sun X, Han R, Wang Z, Chen Y*. Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Diabetologia. 2006 Jun;49(6):1303-10.

34. Kuang C, Xiao Y, Liu X, Stringfield TM, Zhang S, Wang Z, Chen Y*. In vivo disruption of TGF-beta signaling by Smad7 leads to premalignant ductal lesions in the pancreas. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1858-63.

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