edf壹定发

全体研究组长

胡国宏
博士 研究员 博士生导师

中科院肿瘤与微环境重点实验室,肿瘤转移课题组组长

研究方向:肿瘤转移与微环境调控

电子邮件(E-mail ) ghhu@sibs.ac.cn

电话(Tel) : 021-54923296

传真(Fax): 021-54923297

邮政编码: 200031

简历 & 研究方向 

2017-     edf壹定发  研究员,院长助理

2009-2016   edf壹定发上海生命科学研究院/上海交通大学医学院健康科学研究所,研究员

2014-2016   edf壹定发上海生命科学研究院/上海交通大学医学院健康科学研究所,副所长

2011-2014   edf壹定发上海生命科学研究院/上海交通大学医学院健康科学研究所,所长助理

2009-2009年   美国普林斯顿大学分子生物系,Associate Research Scholar

2005-2008   美国普林斯顿大学分子生物系,博士后

2000-2005   美国罗格斯大学(Rutgers University),分子遗传学,博士

1996-2000   清华大学,生物科学与技术系,学士

 

研究方向

1. 转移的微环境调控机制。肿瘤转移是癌症致死的主要原因。癌细胞对其所处微环境的适应及改造对转移过程有重要影响。大家主要研究癌细胞与转移微环境的互作机制,以及这些互作对肿瘤转移能力、转移的器官特异性、癌细胞的转移休眠/重激活状态的调控作用,并进一步发现有效预测肿瘤转移的分子标志物以及靶向肿瘤-微环境互作的策略。

2. 肿瘤干细胞与转移。肿瘤干细胞一般被认为是癌症发生、抗药及复发的“元凶”,但是肿瘤干细胞与转移的关系尚不清楚。大家主要研究肿瘤干细胞在转移中发挥的作用及调控机制,分析肿瘤干细胞的异质性,不同干细胞亚群的转移及调控,肿瘤干细胞与转移微环境的互作等,以期发现通过靶向肿瘤干细胞抑制转移的方法。

3. 肿瘤代谢调控与转移。肿瘤的Warburg效应已经引起广泛关注。大家主要研究在转移过程中的糖脂代谢调控,包括癌细胞自身的代谢异常模式、代谢微环境对癌细胞转移能力以及转移器官特异性的调控作用等。

 

代表性论文(* 通讯编辑

1. Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q*, Hu G*. Differential effects on lung and bone metastasis of breast cancer by Wntsignalling inhibitor DKK1. Nat Cell Biol, 2017; 19(10):1274-1285.

2. Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H*. YAP suppresses lung squamous cell carcinoma progression via deregulation of the DNp63-GPX2 axis and ROS accumulation. Cancer Res, 2017;doi: 10.1158/0008-5472.CAN-17-0449.

3. Hu J#, Li G#, Zhang P, Zhuang X, Hu G*. A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity.Cell Death Dis, 2017;8(3):e2679.

4. Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S,Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of WHSC1 promotes prostate cancer metastasis. J Clin Invest, 2017;127(4):1284-1302.

5. Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q*, Hu G*. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene, 2017; 36(7):989-998

6. Yu PF, Huang Y, Xu CL, Lin LY, Han YY, Sun WH, Hu G, Rabson AB, Wang Y, Shi Y*. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis.Oncogene, 2017;36(6): 840-49.

7. Yu J#, Lei R#, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G*. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun, 2016;7:13884.

8. Chen X, Cao X, Sun X, Lei, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, HouY, Wang M, SiebenlistUt, Chin E, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis, 2016;7(12):e2508.

9. Liang Y#, Hu J#, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G*. Epigenetic activation of TWIST1 by MTDH promotes cancer stem-like Cell traits in breast cancer. Cancer Res, 2015;75:3672.

10. Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y*. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Medicine, 2015;13:45.

11. Wei QLei R, Hu G*. Roles of miR-182 in sensory organ development and cancer. Thorac Cancer. 2015;6;2-9.

12. Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ, Kang Y*. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res, 2014;74(18):5336-47.

13. Lin B#, Wang Y#, Wang Z, Tan H, Kong X, Shu Y, Zhang Y, Huang Y, Zhu Y, Xu H, Wang Z, Wang P, Ning G, Kong X*, Hu G*, Hu L*. Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One, 2014;28;9(2):e90215.

14. WangY, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin E, Kang Y, Yang Q*, Hu G*. DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest, 2014;124(4):1646-59.

15. Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G, Yang Q*. MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene, 2014;33(24):3119-28.

16. Lei R#Tang J#, Zhuang X, Deng R, Li G, Yu J, Liang Y, Xiao J, Wang H-Y, Yang Q, Hu G*. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene, 2014;33(10):1287-96.

17. Zhang N, Wang X, Huo Q, Li X, Wang H-Y, Schneider PHu G*, Yang Q*. The oncogene metadherin modulates the apoptotic pathway based on thetumor necrosis factor superfamily member TRAIL in breast cancer. J BiolChem, 2013;288(13):9396-407.

18. Liang Y, Wu H, Lei R, Chong RA, Wei Y, Lu X, Tagkopoulos I, Kung S-Y, Yang Q, Hu G*, Kang Y*. Transcriptional network analysis identifies BACH1 as amaster regulator of breast cancer bone metastasis. J BiolChem, 2012; 287(40):33533-44.

19. Jin L#, Zhang Y#, Li H, Yao L, Fu D, Yao X, Xu L*, Hu X*, Hu G*. Differential secretomeanalysis reveals CST6 as a suppressor of breast cancer bone metastasis. Cell Res, 2012; 22(9):1356-73.

20. Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X*. ACAP4 cooperates with GRB2 to orchestrate EGF-stimulated integrin beta1 recycling in cell migration. J BiolChem, 2011;286(51):43735-47.

21. Liang Y, Fu D, Hu G*. MTDH: An emerging key regulator of malignant progression in multiple cancers. Thorac Cancer, 2011;2:143-8.

22. Korpal M, Ell B, Buffa F, Khan Z, Blanco M, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Singh M, Harris A, Kang Y*. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med, 2011;17(9):1101-8.

23. Shan J#, Budijono S#, Hu G#, Yao N, Kang Y, Ju Y*, Prud’homme R*. PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenylporphine (TPP) for photodynamic therapy. AdvFunct Mater, 2011;21(13)2488-95.

24. Lu X, Yan C, Yuan M, Wei Y, Hu G, Kang Y*. In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropicmetastasis of breast cancer. Cancer Res, 2010;70(10):3905-14.

25. Hu G, Wei Y, Kang Y*. The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res, 2009;15(18):5615-20.

26. Hu G, Kang Y, Wang X-F*. From breast to the brain: unraveling the puzzle of metastasis organotropism. J Mol Cell Biol, 2009;1(1):3-5.

27. Hu G, Chong R, Yang Q, Wei Y, Li F, Blanco A, Reiss M, Au J-S, Haffty B, Kang Y*. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell, 2009; 15(1):9-20. (Cover article. Rated as “Exceptional” by Faculty 1000 of Biology) 

28. Lu X, Wang Q, Hu G, Poznak CV, Fleisher M, Reiss M, Massagué J, Kang Y*. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.Genes Dev, 2009; 23(16):1882-94.

29. Hu G#, Yang Q#, Yue G, Azaro MA, Wang H-Y, Cui X, Li H. A highly sensitive and specific system for large-scale gene expression profiling. BMC Genomics, 2008; 9:9. (Rated as “Highly Accessed” article by BMC).

30. Korpal M, Lee ES, Hu G, Kang Y*. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J BiolChem, 2008;283:14910-4.

31. Hu G, Wang, H-Y, Frikker DM, Azaro MA, Luo M, Tereshchenko IV, Cui X, Yang J-M, Gao R, Shen L, Li H*. AccuTyping: New algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays.Nucleic Acids Res, 2006; 34(17):e116.

 

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