edf壹定发

全体研究组长

高 莹
博士 研究员 博士生导师

中科院营养代谢与食品安全重点实验室,

表观遗传和营养相关慢性病课题组组长

研究方向:营养分子流行病

电子邮件(E-mail): yinggao@sibs.ac.cn

电话(Tel): 8621 54920985

邮政编码: 200031

简历 & 研究方向
2017-至  今:edf壹定发,研究员
2012-2016:edf壹定发上海生命科学研究院营养科学研究所,研究员
2007-2012:美国国立卫生研究院癌症研究所,博士后
2001-2007:美国康奈尔大学营养系,博士
2001-2007:美国康奈尔大学统计系,硕士
1998-2001:北京大学营养与食品卫生系,硕士

研究方向
以人群研究(流行病学)为基础,结合表观遗传学组学和基因组学等研究方法,系统的探索表观遗传和遗传因素,以及它们与营养等环境因素的相互作用,对生命全程的健康的影响。目前大家主要研究脂肪酸摄入和代谢在代谢紊乱、癌症和 生长发育中的作用。大家也感兴趣与寻找可以和营养因素共同影响疾病危险性的表观遗传因素。大家也计划通过人群干预研究来进一步评价营养因素的疾病预防和治疗潜力。
1. 脂肪酸与癌症、代谢紊乱和生长发育的关系
2. 遗传和表观遗传在癌症病因学中的意义
3. 人群干预研究

代表性论文(*通讯编辑)

  1. Kangning Chen, Qianyu Zhao, Xiaofan Li, Jing Zhao, Peiqin Li, Shuchun Lin, Hongwei Wang, Jiajie Zang, Ying Xiao, Wanghong Xu, Fuxue Chen, Ying Gao*. Dietary fiber intake and endometrial cancer risk: A systematic review and meta-analysis. Nutrients. 2018 Jul 22;10(7). pii: E945.
  2. Jing Zhao, Xiaofan Li, Xiang Li, Qianqian Chu, Yunhua Zhou, Zi Li, Hong Zhang, Thomas J Brenna, Yiqing Song, Ying Gao*. Associations of plasma very long chain saturated fatty acids and metabolic syndrome in Chinese adults. Br J Nutr. 2018 Oct;120(8):855-862
  3. Jie Liu, Shengquan Mi, Li Du, Xiang Li, Jing Zhao, Hong Zhang, WenHua Zhao*, Ying Gao*. The associations between plasma phytoestrogens concentration and metabolic syndrome risks in Chinese population. PLoS One. 2018 Mar 20;13(3):e0194639
  4. Peiqin Li, Jing Zhao, Kumar Kothapalli, Xiang Li, Hui Li, Yuxuan Han, Shengquan Mi, Wenhua Zhao, Qizhai Li, Hong Zhang, Yiqing Song, J. Thomas Brenna, Ying Gao*. A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profilesamong Chinese adults: a population-based study. American Journal of Clinical Nutrition. 2018;107(6):867-875
  5. Xiang Li, Hui Li, Jing Zhao, Qi Dai, Chaoran Huang, Langping Jin, Fan Yang, Fuxue Chen, Ouchen Wang, Ying Gao*. Plasma ω-3 and ω-6 fatty acids in thyroid diseases. Oncology Letters. 2018 Oct;16(4):5433-5440.
  6. Xiaofan Li, Jing Zhao, Peiqin Li, Ying Gao*. Dairy products intake and endometrial cancer risk: a meta-analysis of observational studies. Nutrients. 2017;10(1). pii: E25.
  7. Hui Li, Xiang Li, Jie Liu, Langping Jin, Fang Yang, Junbo Wang, Ouchen Wang, Ying Gao*. Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. Int J Environ Health Res. 2017 Oct;27(5):409-419
  8. 李慧, 郭倩颖, 柳鹏, 张岩春, 戴智勇, 高莹, 王军波. 不同时期母乳中脂肪酸水平的变化. 中国食物与营养. 2017,23(5):54-58
  9. Yanhui Hao, Jing Zhao, Kan Wang, Nannan Feng, Pin Sun, Renjie Chen, Bin Han, Zhipeng Bai, Yiliang Zhu, Ying Gao*, Zhao-lin Xia*. The Association between Particulate Matter Air Pollution and Respiratory Health in Elderly with Type 2 Diabetes Mellitus. Journal of Occupational and Environmental Medicine. 2017;59(9):830-834
  10. Li Du, Yulong Wang, Hang Zhang, Hong Zhang, Ying Gao*. Folate intake and the risk of endometrial cancer: A meta-analysis. Oncotarget. 2016;7(51):85176-85184
  11. Jing Zhao, Lvy Chen, Jian Gao, Li Du, Boer Shan, Hong Zhang, Huaying Wang, Ying Gao*. Dietary fat intake and endometrial cancer risk: a dose-response meta-analysis. Medicine. 2016 Jul;95(27):e4121
  12. Jie Liu, Feixiang Yuan, Jian Gao, Boer Shan, Yulan Ren, Huaying Wang, Ying Gao*. Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials. Oncotarget. 2016;7(14):17369-17379
  13. Jun Han, Yi Jiang, Xiao Liu, Qingyang Meng, Qiulei Xi, Qiulin Zhuang, Yusong Han, Ying Gao, Qiurong Ding, Guohao Wu. Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies. Plos One. 2015;10(9):e0138580
  14. Kristinsson SY#, Gao Y#, Bj?rkholm M, Lund SH, Sj?berg J, Caporaso N, Goldin LR, Landgren O. Hodgkin lymphoma risk following infectious and chronic inflammatory diseases: a large population-based case-control study from Sweden. Int J Hematol. 2015 Jun;101(6):563-568. (#equal contribution)
  15. Jing Zhao, Jing Wang, Jinfeng Du, Hongli Xu, Wei Zhang, Quanxing Ni, Herbert Yu, Harvey A. Risch, Yutang Gao, Ying Gao*. Urinary prostaglandin E2 metabolite and pancreatic cancer risk: case-control study in urban Shanghai. Plos One, 2015;10(2):e0118004
  16. Wenqing Li, Nan Hu, Paula L. Hyland, Ying Gao, Zhaoming Wang, Kai Yu, Hua Su, Chaoyu Wang, Lemin Wang, Stephen J. Chanock, Laurie Burdett, Ti Ding, Youlin Qiao, Jinhu Fan, Yuan Wang, Yi Xu, Jianxin Shi, Fangyi Gu, William Wheeler, Xiaoqin Xiong, Carol Giffen, Margaret A. Tucker, Sanford M. Dawsey, Neal D. Freedman, Christian C. Abnet, Alisa M. Goldstein, Philip R. Taylor. Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. Carcinogenesis, 2013; 34:1536-1542
  17. Ying Gao*, Keith Killian, Hong Zhang, Kai Yu, Qizhai Li, Stephanie Weinstein, Jarmo Virtamo, Margaret Tucker, Philip Taylor, Demetrius Albanes, Paul Meltzer, Neil Caporas. Leukocyte DNA methylation and colorectal cancer among male smokers. World Journal of Gastrointestinal Oncology. 2012;4:193-201
  18. David E. Capo-Ramos, Ying Gao, Jay H. Lubin, David P. Check, Lynn R. Goldin, Angela C. Pesatori, Dario Consonni, Pier Alberto Bertazzi, Andrew J. Saxon, Andrew W. Bergen, Neil E. Caporaso, Maria Teresa Landi. Mood disorders and risk of lung cancer in the EAGLE Case-control study and in the U.S. Veterans Affairs inpatient cohort. Plos One, 2012;7:e42945
  19. Qizhai Li, Dongdong Pan, Weihua Yue, Ying Gao, Kai Yu. Evaluating rare variants under two- stage design. Journal of Human Genetics, 2012;57:352-357
  20. Yoon Jung Park, Herry Herman, Ying Gao, Anders M. Lindroth, Benjamin Y. Hu, Patrick J. Murphy, James R. Putnam, Paul D. Soloway. Sequences sufficient for programming imprinted germ line DNA methylation defined. Plos One, 2012;7:e33024
  21. Ying Gao*, Hormuzd Katki, Barry Graubard, Michael Pollak, Michael Martin, Yuzhen Tao, Robert E. Schoen, Timothy Church, Richard B. Hayes, Mark H. Greene, Sonja I. Berndt. Serum IGF1, IGF2, and IGFBP3 and risk of advanced colorectal adenoma. International Journal of Cancer, 2012;131:E105-113
  22. Gao Y*, Baccarelli A, Shu XO, Ji BT, Yu K, Tarantini L, Yang G, Li HL, Hou L, Rothman N, Zheng W, Gao YT, Chow WH. Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women’s Health Study. British Journal of Cancer, 2012;106:585-591
  23. Freddy Sitas, Sam Egger, Margaret I. Urban, Philip R. Taylor, Christian C. Abnet, Paolo Boffetta, Dianne L. O'Connell, David C. Whiteman, Paul Brennan, Reza Malekzadeh, Michael Pawlita, Sanford M. Dawsey, and Tim Waterboer, on behalf of the InterSCOPE Collaboration. Penelope M. Webb, Adèle C. Green, Nicholas K. Hayward, David Zaridze, Ivana Holcatova, Dana Mates, Neonila Szeszenia-Dabrowska, Gilles Ferro, Vladimir Janout, Maria Paula Curado, Ana Maria Menezes, Sergio Koifman, Farhad Islami, Dariush Nasrollahzadeh, Nan Hu, Alisa M. Goldstein, Ying Gao, Ti Ding, and Farin Kamangar. InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers. J Natl Cancer Inst. 2012 Jan 18;104(2):147–158.
  24. Ying Gao*, Nan Hu, Xiao You Han, Ti Ding, Carol Giffen, Alisa M Goldstein, Philip R Taylor. Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case-control study. Cancer Epidemiology, 2011;35:e91-e99
  25. Ying Gao*, Richard B. Hayes, Wenyi Huang, Neil E. Caporaso, Laurie Burdette, Meredith Yeager, Stephen J. Chanock, Sonja I. Berndt DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas. Carcinogenesis, 2011;32:882-887
  26. Ying Gao*, Nan Hu, XiaoYou Han, Carol Giffen, Ti Ding, Alisa Goldstein, Philip Taylor. Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. BMC Cancer, 2009;9:269
  27. Gao Y*, Hu N, Han X, Giffen C, Ding T, Goldstein AM, Taylor PR. Jasmine tea consumption and upper gastrointestinal cancer in China. Cancer Causes Control. 2009 Dec;20(10):1997-2007.
  28. Xueying Liang, Ying Gao, Tram K Lam, Qizhai Li, Cathy Falk, Xiaohong R Yang, Alisa M Goldstein, Lynn R Goldin. Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods. BMC Proceedings, 2009;3:S79
  29. Ying Gao, Alisa M. Goldstein, Dario Consonni, Angela C. Pesatori, Sholom Wacholder, Margaret A. Tucker, Neil E. Caporaso, Lynn Goldin, Maria Teresa Landi. Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer. International Journal of Cancer, 2009;125:146-152
  30. Gao Y*, Kristinsson SY, Goldin LR, Bj?rkholm M, Caporaso NE, Landgren O. Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association. Gastroenterology. 2009 Jan;136(1):91-98
  31. Ying Gao*, Martha S. Linet, Gloria Gridley, Lene Mellemkjaer, Kari Hemminki, Lynn R. Goldin, Ola Landgren. Shared susceptibility for celiac disease and inflammatory bowel disease? Scand J Gastroenterol. 2008;43(10):1279-1280
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