edf壹定发

全体研究组长

韩敬东
博士 研究员 博士生导师

中科院计算生物学重点实验室,分子系统生物学课题组组长

研究方向:分子系统生物学

电子邮件(E-mail):jdhan@picb.ac.cn

电话(Tel):021-54920458

传真(Fax):021-54920452

邮政编码:200031

课题组网站:http://www.picb.ac.cn/hanlab

简历 & 研究方向

2010-至  今:edf壹定发-马普计算生物学伙伴研究所 研究员,所长

2010-2017中科院计算生物学重点实验室 主任

2005-2010中科院遗传与发育生物学研究所 分子系统中心主任,研究员

2002-2005美国哈佛大学医学院 博士后

2001-2002美国CQOS企业 工程师

2000-2001美国Rare Medium企业 App开发

1999-2000美国NorthStar科技企业 工程师

1997-1998美国洛克菲勒大学 博士后

 

研究方向(1000字以内)

本课题组主要从事分子系统生物学研究工作,具体包括:

1.研究生物网络的结构、动态及其功能;

2.通过表观组学、功能基因组学及整合网络分析,寻找衰老及干细胞分化相关的关键基因,并进一步研究分子及功能作用机制;

3.探求遗传基因网络中内在的安全稳定机制。

 

学术任职

Journal of Biological ChemistryFrontiers in Biology Quantitative BiologyAging CellJournal of Computational Biology等杂志编委,Journal of Genomics and Genetics, Special Issue on Aging杂志责任编辑

 

代表性论文(* 通讯编辑

1. Na Sun^, Xiaoming Yu^, Fang Li^, Denghui Liu, Shengbao Suo, Weiyang Chen, Shirui Chen, Lu Song, Christopher D. Green, Joseph McDermott, Qin Shen, Naihe Jing & Jing-Dong J. Han. Inference of differentiation time for single cell transcriptomes using cell population reference data. Nature Communications. 2017 Nov 30;8(1):1856

2. Xinyi Wang^, Denghui Liu^, Dajian He, Shengbao Suo, Xian Xia, Xiechao He, Jing-Dong J. Han*, and Ping Zheng*. Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos. Genome Research. 2017 Apr;27(4):567-579. doi: 10.1101/gr.198044.115. Epub 2017 Feb 21.

3. Guangdun Peng^, Shengbao Suo^, Jun Chen^, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Guizhong Cui, Lu Song, Patrick P.L. Tam, Jing-Dong J. Han*, Naihe Jing*. Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell, 2016 Mar 21;36(6):681-97. doi: 10.1016/j.devcel.2016.02.020.

4. Lei Hou, Dan Wang, Di Chen, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, and William B. Mair and Jing-Dong J. Han*. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 8;23(3):529-40.

5. Yi Huang, Xiaoming Yu, Na Sun, Nan Qiao, Yaqiang Cao, Jerome D. Boyd-Kirkup, Qin Shen, and Jing-Dong J Han. Single-cell level spatial gene expression in the embryonic neural differentiation niche. Genome Research. 2015 Apr;25(4):570-81.

6. Weiyang Chen, Wei Qian, Gang Wu, Weizhong Chen, Bo Xian, Xingwei Chen, Yaqiang Cao, Christopher D Green, Fanghong Zhao, Kun Tang and Jing-Dong J. Han*, Three-dimensional human facial morphologies as robust aging markers, Cell Research, 2015, 25:574-587 (highlighted by Nature Press Release, Science News, New Scientists, The Guardian, Daily Mail, and NewsWeek, etc).

7. Weizhong Chen, Yi Liu, Shanshan Zhu, Christopher D. Green, Gang Wei, Jing-Dong J. Han*, Improved Nucleosome Positioning Algorithm iNPS for Accurate Nucleosome Positioning from Sequencing Data, Nature Communications 2014, doi:10.1038/ncomms5909.

8. Ming Su, Dali Han, Jerome D Boyd-Kirkup, Xiaoming Yu and Jing-Dong J Han*Evolution of Alu towards enhancers, Cell Reports, 2014, 7(2): 376-385

9. Jin’e Li, Yi Liu, Min Liu and Jing-Dong J Han*Functional dissection of regulatory models using gene expression data of deletion mutants, PLoS Genetics, 2013, 9(9): e1003757.

10. Wei Zhang, Yi Liu, Na Sun, Dan Wang, Jerome Boyd-Kirkup, Xiaoyang Dou, Jing-Dong J Han*, Integrating Genomic, Epigenomic and Transcriptomic Features Reveals Modular Signatures Underlying Poor Prognosis in Ovarian Cancer, Cell Reports, 2013, 4(3):542–553

11. Yi Liu, Nan Qiao, Shanshan Zhu, Ming Su, Na Sun, Jerome Boyd-Kirkup, Jing-Dong J. Han*. A novel Bayesian network inference algorithm for integrative analysis of heterogeneous deep sequencing data. Cell Research. 2013 Mar;23(3):440-3.

12. Zhou, B., Yang, L., Li, S.F., Huang, J.L., Chen, H.Y., Hou, L., Wang, J.B., Green, C.D., Yan, Z., Huang, X., Zhu L., Xiao H.S., Liu Y. *, and Han J.D.J. * (2012). Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions, Proc Natl Acad Sci U S A. 8;109(19):E1201-9.

13. Jin, C., Li, J., Green, C.D., Yu, X. , Tang, X, Han, D., Xian, Bo., Wang, D, Huang, X., Cao, X., Yan. Z., Hou, L., Liu, J., Shukeir, N., Khaitovich, P., Chen, C.D., Zhang, H., Jenuwein, T. and  Han, J.-D.J *, Histone Demethylase UTX-1 Regulates C. elegans Lifespan by Targeting Insulin/IGF-1 Signaling Pathway, Cell Metabolism, 2011, 14: 16

 

 

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