edf壹定发

全体研究组长

余 鹰(客座)
博士 研究员 博士生导师

中科院营养代谢与食品安全重点实验室 炎症与心血管病课题组组长

电子邮件(E-mail ) yuying@tmu.edu.cn

电话(Tel) 022-83336627

传真(Fax) 022-83336627

邮政编码 ?300070

简历 & 研究方向

2017-     天津医科大学基础医学院药理学系,教授

2017-至  今   edf壹定发 研究员

2009-2016年   edf壹定发上海生命科学研究院营养科学研究所,研究员

2008 -2009  美国宾夕法尼亚大学,心血管疾病动物模型中心主任

2006-2009   美国宾夕法尼亚大学医学院转化医学研究所,Research Associate

2002-2006   美国宾夕法尼亚大学医学院药理系,博士后

1998-2001   中南大学湘雅医学院病理生理系,病理生理学博士

1995-1998   南昌大学医学院病理生理学教研室,病理生理学硕士

1990-1995   南昌大学医学院临床医学系,学士

 

研究方向

1,利用转基因小鼠结合易感人群分析研究环氧合酶(COX),Ω3/脂肪酸(EPADHA)和前列腺素产物在心脏重塑与血管损伤中作用;2,前列腺素及其受体在糖脂代谢与糖尿病并发血管性疾病中作用

 

学术任职

Frontiers in Pharmacology,副主编;

Cardiovascular Research,编委;

中国病理生理学会心血管专业青年委员会,副主任委员

 

代表性论文(* 通讯编辑

1. Zuo S, Kong D, Wang C, Liu J, Wang Y, Wan Q, Yan S, Zhang J, Tang J, Zhang Q, Lyu L, Li X, Shan Z, Qian L, Shen Y*, Yu Y*. CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain. EMBO Mol Med. 2018 Jan 15. pii: e8237. doi: 10.15252/emmm.201708237

2. Chen G, Zuo S,Tang J,Zuo C,Jia D,Liu Q, Liu G,n Zhu Q, Wang Y, Zhang J, Shen Y, Che D, Yuan P, Qin Z, Ruan C,Ye J, Wang XJ, Zhou Y, Gao P, Zhang P, Liu J,Jing ZC, Lu A, Yu Y* . Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice. J Exp Med. 2018, In press.

3. Tang J, Shen Y, Chen G, Wan Q, Wang K, Zhang J, Qin J, Liu G, Zuo S, Tao B, Yu Y, Wang J, Lazarus M, Yu Y*. Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nat Commun. 2017;8:14656.

4. Yan S, Tang J, Zhang Y, Wang Y, Zuo S, Shen Y, Zhang Q, Chen D, Yu Y, Wang K, Duan S*, Yu Y*. Prostaglandin E2 Promotes Hepatic Biliary Cholesterol Excretion by E Prostanoid Receptor 3 Mediated Hepatocyte Nuclear Receptor 4α/Cholesterol 7α-Hydroxylase Pathway in Mice. Hepatology. 2017,65(3):999-1014.

5. Li J, Kong D, Wang Q, Wu W, Tang Y, Bai T, Guo L, Wei L, Zhang Q, Yu Y, Qian Y, Zuo S, Liu G, Liu Q, Wu S, Zang Y, Zhu Q, Jia D, Wang Y, Yao W, Ji Y, Yin H, Nakamura M, Lazarus M, Breyer RM, Wang L*, Yu Y*. Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation. EMBO Mol Med. 2017;9(5):571-588.

6. Kong D, Shen Y, Liu G, Zuo S, Ji Y, Lu A, Nakamura M, Lazarus M, Stratakis CA, Breyer RM, Yu Y*. PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation. J Exp Med. 2016;213(10):2209-26.

7. Shen Y, Zuo S, Wang Y, Shi H, Yan S, Chen D, Xiao B, Zhang J, Gong Y, Shi M, Tang J, Kong D, Lu L, Yu Y, Zhou B, Duan SZ, Schneider C, Funk CD, Yu Y*. Thromboxane governs the differentiation of adipose-derived stromal cells toward endothelial cells in vitro and in vivo. Circ Res. 2016 Apr 15;118(8):1194-207.

8. Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Fei X, Yuan F, Zhou B, Duan S, Yu Y, Lazarus M, Su Y, Breyer RM, Funk CD, Yu Y*. EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling. J Clin Invest. 2015; 125(3):1228-42.

9. Shi M, Shi G, Tang J, Kong D, Bao Y, Xiao B, Zuo C, Wang T, Wang Q, Shen Y, Wang H, Funk CD, Zhou J*, Yu Y*. Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyper-responsiveness. J Allergy Clin Immunol. 2014;134(5):1163-74.

10. Yang Q, Shi M, Shen Y, Cao Y, Zuo S, Zuo C, Zhang H, Gabrilovich DI, Yu Y*, Zhou J*. COX-1 derived thromboxane A2 plays an essential role in early B cell development via regulation of JAK/STAT5 signaling in mouse. Blood. 2014;124(10):1610-21.

11. Yan S, Zhang Q, Zhong X, Tang J, Wang Y, Yu J, Zhou Y, Zhang J, Guo F, Liu Y, FitzGerald GA, Yu Y*. I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT. Diabetes. 2014 Sep;63(9):2911-23

12. Zhang J, Zou F, Tang J, Zhang Q, Gong Y, Wang Q, Shen Y, Xiong L, Breyer RM, Lazarus M, Funk CD, Yu Y*. COX-2-Derived PGE2 Promotes Injury-induced Vascular Neointimal Hyperplasia through the the E-prostanoid 3 receptor. Circ Res. 2013; 113(2):104-14.

 

 

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