edf壹定发

全体研究组长

谢 东

中科院营养代谢与食品安全重点实验室,肿瘤分子生物学课题组组长

研究方向:肿瘤发生和转移过程中的分子机制研究

电子邮件(E-mail):dxie@sibs.ac.cn

电话(Tel):021-54920918

传真(Fax):021-54920291

邮政编码:200031

课题组网站:

简历 & 研究方向
2017-至  今  edf壹定发 研究员
2004-2016年 edf壹定发上海生命科学研究院营养科学研究所 研究员
2000-2004年 美国加州大学洛杉矶分校(UCLA)医学院 助理教授
1997-2000年 美国加州大学洛杉矶分校西赛医学中心 博士后
1992-1997年 美国南卡罗来纳大学 分子生物系 博士
1989-1992年 东华理工大学 讲师
1986-1989年 edf壹定发遗传所 硕士
1983-1986年 东华理工大学 助教
1979-1983年 江西大学(现南昌大学)生物系 学士

研究方向(1000字以内)
1. 利用细胞及动物模型并结合临床样本,研究酪氨酸受体激酶Eph/ephrin家族成员在肿瘤发生发展中的双重调控作用机理和信号转导。
2. 接头蛋白RACK1生物学功能研究,包括RACK1对Wnt、Hedgehog等信号通路的影响,及RACK1在炎症、干扰素相关肿瘤免疫中的作用及信号转导。
3. 针对Ephs/ephrins及相关分子的药物靶标筛选,探寻肿瘤起始细胞(Tumor Initiating Cells, TICs)与药物抗性之间的联系,开发新的治疗肿瘤的药物。

代表性论文(* 通讯编辑)

  1. Chen TW, Yin FF, Yuan YM, Guan DX, Zhang E, Zhang FK, Jiang H, Ma N, Wang JJ, Ni QZ, Qiu L, Feng J, Zhang XL, Bao Y, Wang K, Cheng SQ, Wang XF, Wang X, Li JJ, Xie D* (2019) Liver Cancer: CHML promotes metastasis by facilitating Rab14 recycle. Nat Commun 2019 Jun 7;10(1):2510. doi: 10.1038/s41467-019
  2. Yuan YM, Ma N, Zhang EB, Chen TW, Jiang H, Yin FF, Wang JJ, Zhang FK, Ni QZ, Wang X, Bao Y, Wang K, Cheng SQ, Zhang XL, Wang XF, Li JJ, Xie D* (2019) BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis. Oncogene 2019 Aug 15. doi: 10.1038/s41388-019-0943-y. [Epub ahead of print]
  3. Deng YZ, Cai Z, Shi S, Jiang H, Shang YR, Ma N, Wang JJ, Guan DX, Chen TW, Rong YF, Qian ZY, Zhang EB, Feng D, Zhou QL, Du YN, Liu DP, Huang XX, Liu LM, Chin E, Li DS, Wang XF, Zhang XL, Xie D* (2018) Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. J Exp Med 2;215(1):177-195
  4. Cai Z, Qian ZY, Jiang H, Ma N, Li Z, Liu LY, Ren XX, Shang YR, Wang JJ, Li JJ, Liu DP, Zhang XP, Feng D, Ni QZ, Feng YY, Li N, Zhou XY, Wang X, Bao Y, Zhang XL, Deng YZ, Xie D* (2018) hPCL3s Promotes Hepatocellular Carcinoma Metastasis by Activating β-Catenin Signaling. Cancer Res 15;78(10):2536-2549
  5. Zhou W, Ye XL, Xu J, Cao MG, Fang ZY, Li LY, Guan GH, Liu Q, Qian YH, Xie D* (2017) The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b. Science signaling 10(483). pii: eaak9557
  6. Li JJ, Sun ZJ, Yuan YM, Yin FF, Bian YG, Long LY, Zhang XL, Xie D* (2017) EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer. J Biol Chem 292(3): 1112-1121
  7. Bao WD, Fan Y, Deng YZ, Long LY, Wang JJ, Guan DX, Qian ZY, Feng YY, He ZY, Wang XF, Phillip Koeffler H, Hu R, Wang J, Wang X, Wang F, Li JJ, Xie D* (2016) Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. J Hepatol 65(1):137-145
  8. Guan DX, Shi J, Zhang Y, Zhao JS, Long LY, Chen TW, Zhang EB, Feng YY, Bao WD, Deng YZ, Qiu L, Zhang XL, Koeffler HP, Cheng SQ, Li JJ, Xie D* (2015) Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. Hepatology 62(6):1791-1803
  9. Li, JJ, Xie D* (2015) RACK1, a versatile hub in cancer. Oncogene 9;34(15):1890-1898
  10. Long L, Deng Y, Yao F, Guan D, Feng Y, Jiang H, Li X, Hu P, Lu X, Wang H, Li J, Gao X, Xie D* (2014) Recruitment of Phosphatase PP2A by RACK1 Adaptor Protein Deactivates Transcription Factor IRF3 and Limits Type I Interferon Signaling. Immunity 40: 515-529
  11. Yao F, Long LY, Deng YZ, Feng YY, Ying GY, Bao WD, Li G, Guan DX, Zhu YQ, Li JJ, Xie D* (2014) RACK1 Modulates NF-κB Activation by Interfering with the Interaction between TRAF2 and the IKK Complex. Cell Research 24(3):359-371
  12. Zhang Y, Guan DX, Shi J, Gao H, Li JJ, Zhao JS, Qiu L, Liu J, Li N, Guo WX, Xue J, Zhou FG, Wu MC, Wang HY, Xie D*, Cheng SQ* (2013) All-trans retinoic acid potentiates the chemotherapeutic effect of Cisplatin by inducing differentiation of tumor initiating cells in liver cancer. J Hepatol 6:1255-1263
  13. Yang, P., Li, Q.J., Feng, Y., Zhang, Y., Markowitz, G.J., Ning, S., Deng, Y., Zhao, J., Jiang, S., Yuan, Y., Wang, H.Y., Cheng, S.Q., Xie, D.*, and Wang, X.F.* (2012) TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell 22(3): 291-303
  14. Li, G., Ji, X.D., Gao, H., Zhao, J.S., Xu, J.F., Sun, Z.J., Deng, Y.Z., Shi, S., Feng, Y.X., Zhu, Y.Q., Wang, T., Li, J.J., and Xie, D.* (2012) EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Aktsignalling complex. Nat Commun 3: 667
  15. Deng, Y.Z., Yao, F., Li, J.J., Mao, Z.F., Hu, P.T., Long, L.Y., Li, G., Ji, X.D., Shi, S., Guan, D.X., Feng, Y.Y., Cui, L., Li, D.S., Liu, Y., Du, X., Guo, M.Z., Xu, L.Y., Li, E.M., Wang, H.Y., and Xie, D.* (2012) RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex. Gastroenterology 142(4): 812-823.e815
  16. Shi, S., Deng, Y.Z., Zhao, J.S., Ji, X.D., Shi, J., Feng, Y.X., Li, G., Li, J.J., Zhu, D., Koeffler, H.P., Zhao, Y., and Xie, D.* (2012) RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J Biol Chem 287(11): 7845-7858
  17. Feng, Y.X., Wang, T., Deng, Y.Z., Yang, P., Li, J.J., Guan, D.X., Yao, F., Zhu, Y.Q., Qin, Y., Wang, H., Li, N., Wu, M.C., Wang, H.Y., Wang, X.F., Cheng, S.Q. and Xie, D.* (2011) Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology 53(2): 483-492
  18. Ji, X.D., Li, G., Feng, Y.X., Zhao, J.S., Li, J.J., Sun, Z.J., Shi, S., Deng, Y.Z., Xu, J.F., Zhu, Y.Q., Koeffler, H.P., Tong, X.J., and Xie, D.* (2011) EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. Cancer Res 71(3): 1156-1166
  19. Feng, Y.X., Zhao, J.S., Li, J.J., Wang, T., Cheng, S.Q., Yuan, Y., Wang, F., Wang, X.F., and Xie, D.* (2010) Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. Hepatology 51(2): 535-544
  20. Cai, Z., Zhao, J.S., Li, J.J., Peng, D.N., Wang, X.Y., Chen, T.L., Qiu, Y.P., Chen, P.P., Li, W.J., Xu, L.Y., Li, E.M., Tam, J.P., Qi, R.Z., Jia, W.*, and Xie, D.* (2010) A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics 9(12): 2617-2628
  21. Li, J.J., Liu, D.P., Liu, G.T., and Xie, D.* (2009) EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene 28(15): 1759-1768
  22. Wang, Y., Liu, D., Chen, P., Koeffler, H.P., Tong, X., and Xie, D.* (2008) Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers. Cancer Res 68(4): 1136-1143
  23. Wang, Y., Liu, D.P., Chen, P.P., Koeffler, H.P., Tong, X.J., and Xie, D.* (2007) Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers. Cancer Res 67(6): 2535-2543
  24. Deng, Y.Z., Chen, P.P., Wang, Y., Yin, D., Koeffler, H.P., Li, B., Tong, X.J., and Xie, D.* (2007) Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. J Biol Chem 282(50): 36571-36581
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