edf壹定发

全体研究组长

魏 刚
博士 研究员 博士生导师

中科院计算生物学重点实验室,表观遗传组学课题组组长

研究方向:发育和疾病的表观遗传调控

电子邮件(E-mail):weigang@picb.ac.cn

电话(Tel):86-21-54920557

传真(Fax):86-21-54920557

邮政编码:200031

课题组网站:http://www.picb.ac.cn/epigenome/

简历 & 研究方向

2012-至  今 edf壹定发-马普计算生物学伙伴研究所 研究员

2005-2011年 美国国家健康研究院博士后
2000-2005年 北京大学 生命科学学院 博士
1996-2000年 北京大学 生命科学学院 学士

研究方向(1000字以内)

1. 细胞命运决定过程中的表观遗传调控机制
2. 疾病的表观遗传调控
3. 染色质高级结构的变化规律和调控功能

代表性论文(* 通讯编辑)

    1. Gao Y, Zhang X, Zhang L, Cen J, Ni X, Liao X, Yang C, Li Y, Chen X, Zhang Z, Shu Y, Cheng X, Hay DC, Lai D, Pan G, Wei G* and Hui L*. Distinct gene expression and epigenetic signatures in hepatocyte-like cells produced by different strategies from the same donor. Stem Cell Reports, 2017, 9: 1813-1824.

    2. Han Z and Wei G*. Computational tools for Hi-C data analysis. Quantitative Biology, 2017, 5: 215-225.

    3.    Ji S, Zhu L, Gao Y, Zhang X, Yan Y, Cen J, Li R, Zeng R, Liao L, Hou C, Gao Y, Gao S, Wei G* and Hui L*. Baf60B-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening. Cell Research, 2017, 27: 642-656.

    4.   Lv X, Han Z, Chen H, Yang B, Yang X, Xia Y, Pan C, Fu L, Zhang S, Han H, Wu M, Zhou Z, Zhang L, Li L, Wei G* and Zhao Y*. A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Research, 2016, 26: 529-542.

    5.    Zhao QY, Lei PJ, Zhang X, Zheng JY, Wang HY, Zhao J, Li YM, Ye M, Li L, Wei G* and Wu M*. Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. Clinical Epigenetics, 2016, 8: 34.  

    6. Gu J, Wang D, Zhang J, Zhu Y, Li Y, Chen H, Shi M, Wang X, Shen B, Deng X, Zhan Q, Wei G* and Peng C*. GFRalpha2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer. Cancer Letters, 2016, 380: 434-441.

    7. Chepelev I, Wei G, Wangsa D, Tang Q and Zhao K. Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Research, 2012, 22: 490-503.

    8. Wei G, Abraham BJ, Yagi R, Jothi R, Cui K, Sharma S, Narlikar L, Northrup DL, Tang Q, Paul WE, Zhu J and Zhao K. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity, 2011, 35: 299-311.

    9. Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ and Zhao K. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity, 2009, 30: 155-167.

    10. Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, Wei G, Chepelev I and Zhao K. High-resolution profiling of histone methylations in human genome. Cell, 2007, 129: 823-837.

    11.    Roh T, Wei G, Farrel C and Zhao K. Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns. Genome Research, 2007, 17: 74-81.

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